Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 80, Issue 7, Pages 1386-1389Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2016.1156483
Keywords
GNRA tetraloop; RNA motif; riboswitch; ribozyme; tertiary interaction
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [23119005, 15K05561, 26891009]
- Grants-in-Aid for Scientific Research [15K05561, 26891009] Funding Source: KAKEN
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Tertiary interactions between a new RNA motif and RNA tetraloops were analyzed to determine whether this new motif shows preference for a GCGA tetraloop. In the structural context of a ligase ribozyme, this motif discriminated GCGA loop from 3 other tetraloops. The affinity between the GCGA loop and its receptor is strong enough to carry out the ribozyme activity.
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