Journal
PROGRESS IN POLYMER SCIENCE
Volume 98, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2019.101161
Keywords
Supercritical fluid; Lipase; Biodegradable polyester; Biomedical engineering; Microcapsule; Microcellular scaffold
Categories
Funding
- Cornell Startup Fund by Cornell University
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Supercritical fluid technology has emerged as a cost-effective and low-hazard alternative to solvent-based methodologies in polymer synthesis, pharmaceutical science, and related biomedical applications. In this review, we first briefly describe the distinctive features of a supercritical fluid, biodegradable polyesters, and lipases. We will then cover the latest progress of supercritical fluid technology in polymerization. Lipase-catalyzed polymerization in supercritical carbon dioxide (SC-CO2) will be the focus of the synthesis section. The last section presents the biomedical applications employing SC-CO2 polymerization, including microcapsule formation for drug delivery, microcellular scaffold fabrication, and SC-CO2 assisted processes for polymer-based treatments, such as surface functionalization, aerogel formation, and fine particle formation. Each topic is illustrated with the most successful examples. Understanding the current progress in SC-CO2 polymerization is an essential step to facilitate the exploration with this green technology in new research frontiers. (C) 2019 Elsevier B.V. All rights reserved.
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