Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 151, Issue -, Pages 40-53Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2019.11.007
Keywords
Triple negative breast cancer; Molecular mechanisms; Treatment methods; Recurrence; Metastasis
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Funding
- National Natural Science Foundation of China [11202167, U1632126]
- Fundamental Research Funds for the Central Universities [3102019ghxm017]
- China Postdoctoral Science Foundation [2013T60890, 2017M623248]
- Shaanxi Postdoctoral Science Foundation [2018BSHEDZZ02]
- Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University [ZZ2019043]
- Undergraduate Training Programs for Innovation and Entrepreneurship in China [201810699351]
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Breast cancer (BC) is a serious worldwide disease that threatens women's health. Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other BC types due to its high molecular heterogeneity, metastatic potential and poor prognosis. TNBC lacks of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), so there are still no effective treatment methods for TNBC. Here, we reviewed the classification of TNBC, its molecular mechanisms of pathogenesis, treatment methods and prognosis. Finding effective targets is critical for the treatment of TNBC. Also, refining the classification of TNBC is benefited to choose the treatment of TNBC, because the sensitivity of chemotherapy is different in different TNBC. Some new treatment methods have been proposed in recent years, such as nutritional therapy and noncoding RNA treatment methods. There are some disadvantages, such as the side effect on normal cells after nutrient deprivation, low specificity and instability of noncoding RNA. More studies are necessary to improve the treatment of TNBC. (C) 2019 Elsevier Ltd. All rights reserved.
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