Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 51, Pages 26049-26056Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1915149116
Keywords
phyB; COP1; BBX4; photomorphogenesis; light signaling
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Funding
- National Key R&D Program of China [2017YFA0503800]
- National Natural Science Foundation of China [31621001, 31900210, 31970258]
- Peking-Tsinghua Center for Life Sciences, Southern University of Science and Technology
- Nanjing Agricultural University
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Phytochrome B (phyB) absorbs red light signals and subsequently initiates a set of molecular events in plant cells to promote photomorphogenesis. Here we show that phyB directly interacts with B-BOX CONTAINING PROTEIN 4 (BBX4), a positive regulator of red light signaling, and positively controls its abundance in red light. BBX4 associates with PHYTOCHROME INTERACTING FACTOR 3 (PIF3) and represses PIF3 transcriptional activation activity and PIF3-controlled gene expression. The degradation of BBX4 in darkness is dependent on CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) and the 26S proteasome system. Collectively, BBX4 acts as a key component of the phyB-PIF3-mediated signaling module and fine tunes the red light action. phyB promotes the accumulation of BBX4, which in turn serves to repress PIF3 action through direct physical interaction to promote photomorphogenic development in red light.
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