Journal
PLASMA PROCESSES AND POLYMERS
Volume 17, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201900103
Keywords
cancer; cell culture; cold plasma; selectivity; therapy
Funding
- U.S. Department of Energy [DE-SC0001939]
- Burroughs Wellcome Fund
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Cold atmospheric plasma (CAP) produces reactive oxygen species and reactive nitrogen species, which may disproportionally damage tumor cells, resulting in potentially selective cancer therapy. Here, we compare the effects of two CAP sources, that is, the atmospheric pressure plasma jet and the surface micro discharge, on the selectivity of CAP-treated cell-culture media. CAP-treated media were applied to metastatic breast tumor cells and their normal breast epithelial cell counterparts to assess treatment selectivity, while systematically varying common cell-culture media and cell-matrix binding moieties. We show that media compositions are crucial in a CAP-treated media selectivity, while binding moieties (specifically, collagen I, fibronectin, and poly-d-lysine) play a lesser role. These data have further implications in the translation of CAP to in vivo use.
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