Journal
PHYTOCHEMISTRY LETTERS
Volume 33, Issue -, Pages 12-16Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2019.06.009
Keywords
Delphinium naviculare var. lasiocarpum; Diterpenoid alkaloids; Naviconine; Naviculine; Naviconitine; Cytotoxicity
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Funding
- West Light Foundation of Chinese Academy of Sciences [2015-XBQN-B-14]
- National Key R&D Program of China [2016YFE0120700]
- International Science & Technology Cooperation of the Xinjiang Uygur Autonomous Region [20166014]
- Central Asian Drug Discovery & Development Centre of Chinese Academy of Sciences
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Three new diterpenoid alkaloids, designated naviconine (1), naviculine (2) and naviconitine (3), together with five known diterpenoid alkaloids (4)-(8) were isolated from the whole plant of Delphinium naviculare var. lasiocarpum W. T. Wang. The structures of the new compounds were established on the basis of spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR analyses. All of the compounds were evaluated in vitro for cytotoxicity against HT-29, MDA-MB-231 and HeLa cancer cell lines using the MTT method.
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