4.3 Article

Three new diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang

Journal

PHYTOCHEMISTRY LETTERS
Volume 33, Issue -, Pages 12-16

Publisher

ELSEVIER
DOI: 10.1016/j.phytol.2019.06.009

Keywords

Delphinium naviculare var. lasiocarpum; Diterpenoid alkaloids; Naviconine; Naviculine; Naviconitine; Cytotoxicity

Funding

  1. West Light Foundation of Chinese Academy of Sciences [2015-XBQN-B-14]
  2. National Key R&D Program of China [2016YFE0120700]
  3. International Science & Technology Cooperation of the Xinjiang Uygur Autonomous Region [20166014]
  4. Central Asian Drug Discovery & Development Centre of Chinese Academy of Sciences

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Three new diterpenoid alkaloids, designated naviconine (1), naviculine (2) and naviconitine (3), together with five known diterpenoid alkaloids (4)-(8) were isolated from the whole plant of Delphinium naviculare var. lasiocarpum W. T. Wang. The structures of the new compounds were established on the basis of spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR analyses. All of the compounds were evaluated in vitro for cytotoxicity against HT-29, MDA-MB-231 and HeLa cancer cell lines using the MTT method.

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