Journal
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
Volume 531, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.physa.2019.121793
Keywords
Star polymers; Micelles; Drug delivery; Random walk; Release kinetics
Categories
Ask authors/readers for more resources
A previously studied drug delivery systems based on 4-arm star shaped polyacids with pentaerythritol core have been proposed as excellent micellar nanocarriers with adjustable characteristics for drug loading and release, including anti-inflammatory drugs. A series of experiments to measure the release of drugs by micelles of various composition were conducted. Here we model this release process by mathematical methods and conclude about the structure and loading capability of the obtained micelles in relation to their composition. Our method is a random walk simulation in a potential field. The results predict a decreasing dependency of the micelle core size on hydrophobic content which relates to the loading capability and release kinetics. We link this phenomenon to the packing quality of the micelle's core, which is reflected by the values of the drug's binding energy to the core and the probability to incorporate the drug into the core. (C) 2019 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available