Journal
PEDIATRIC CLINICS OF NORTH AMERICA
Volume 66, Issue 5, Pages 897-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcl.2019.06.010
Keywords
Humoral immune deficiency; Immunoglobulin deficiency; B cell deficiency; Antibody deficiency
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The most common primary immune deficiencies are those of the humoral immune system, and most of these present in childhood. The severity of these disorders ranges from transient deficiencies to deficiencies that are associated with a complete loss of ability to make adequate or functional antibodies, and have infectious as well as noninfectious complications. This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects.
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