Clinicopathological and prognostic significance of TINCR in caner: A meta-analysis

Background In a variety of cancers, the expression of TINCR is linked to the development, progression, metastasis, invasion, and prognosis of cancer. Our study is the first study used meta-analysis to explore the relationship between TINCR expression and cancer. Methods: By looking up PubMed, Web of Science, CNKI database, we obtained 10 articles for analysis. The statistical analysis was all calculated by Stata 15.1 software. Results: We found that the expression of TINCR was a risk factor to the size of the tumor (OR = 1.772, 95%CI: 1.246-2.520, P = 0.001). In univariate analysis, patients with high expression of TINCR had poor OS (pooled HR = 1.533, 95%CI: 1.025-2.294, P = 0.038). Similar result was also found in multivariate analysis In subgroup analysis (pooled HR = 1.610, 95%CI: 1.356-1.913, P = 0.000).We also found that over-expression of TINCR had poor OS in breast cancer (pooled HR = 1.582, 95%CI: L126-2.223, P = 0.008). Conclusion: In this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer.