Journal
ORGANIC LETTERS
Volume 21, Issue 23, Pages 9763-9768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03970
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Funding
- NNSFC [21971081, 21622201, 91856119, 21820102003, 21772053]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
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Catalytic enantioselective chemical reactions involving highly reactive radical species remain largely unexplored. We report herein for the first time a novel enantioselective radical ring-opening cyanation of redox-active oxime esters by dual photoreodox and copper catalysis. This mild protocol shows good functional group tolerance and broad substrate scope, producing a wide range of optically active alkyl dinitriles with high yields and excellent enantioselectivities, which are difficult to access traditionally.
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