Journal
ORGANIC LETTERS
Volume 21, Issue 23, Pages 9667-9671Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03806
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Funding
- National Science Center, Poland [2016/23/N/ST5/00101]
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An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.
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