Journal
ORGANIC LETTERS
Volume 21, Issue 22, Pages 9019-9023Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03418
Keywords
-
Categories
Funding
- Japan Agency for Medical Research and Development (AMED) [JP19am0101098, JP19 cm0106109]
- JSPS KAKENHI [JP18H02104, JP15H05721, JP18H04386, JP19K05451, JP17J08217]
- Cooperative Research Project of Research Center for Biomedical Engineering
- Naito Foundation
Ask authors/readers for more resources
A synthetic method for diverse gamma-aryl-beta-ketoesters through gamma-aryl-beta-ketoester-type arynes triggered by C-C bond cleavage has been developed. The Mukaiyama aldol reaction of 6-(triflyloxy)benzocyclobutenones with ketene silyl acetals and subsequent treatment of resulting 6-(triflyloxy)benzocyclobutenols with a base triggered the efficient generation of gamma-aryl-beta-ketoester-type arynes, which reacted with various arynophiles to provide a wide range of yaryl-beta-ketoesters. The synthetic utility of the method was demonstrated by the synthesis of an analog of ALK inhibitor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available