Journal
ORGANIC LETTERS
Volume 21, Issue 21, Pages 8582-8586Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03178
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Funding
- National Natural Science Foundation of China [21572150, 21971176]
- Program for New Century Excellent Talents in University [NCET-12-0743]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A chiral N-heterocyclic-carbene-catalyzed cascade asymmetric desymmetrization reaction of cyclopentenediones with enals has been successfully initiated, followed with tandem aldol annulation, aromatization, as well as sequential methylation. The reactions proceeded well under mild reaction conditions, with broad substrate scope and good functional group tolerance, providing a rapid access to highly functionalized chiral 2,2-disubstituted 1,3-indandione derivatives containing an all-carbon quaternary stereogenic center in moderate to good yields with high enantioselectivities.
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