Journal
ORGANIC LETTERS
Volume 21, Issue 21, Pages 8861-8866Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03566
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- University de Strasbourg
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The rhodium-catalyzed hydroformylation of ynamides is described and gives selective access to 2- or 3-aminoacrolein derivatives. The regioselectivity of this carbonylation can be completely controlled at will thanks to the nature of the ligand used. This represents the first example of regiodivergent alkyne hydroformylation. The influence of the substituents on the different positions of the ynamide has been investigated, and it appears that this reaction is tolerant to a wide range of functional groups.
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