Journal
ORGANIC LETTERS
Volume 21, Issue 21, Pages 8635-8640Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03245
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Funding
- Monash University through the office of the Vice-Provost for Research and Research Infrastructure (VPRRI) at Monash University
- Bioplatforms Australia (BPA) as part of the National Collaborative Research Infrastructure Strategy (NCRIS)
- National Health and Medical Research Council [APP1140619]
- Australian Research Council's Discovery Projects funding scheme [DP170102220]
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Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging to synthesize due to their heavily cross-linked structures. Here, we report an optimized method that generates >75% tricyclic peptides from synthetic precursors in order to explore the acceptance of novel GPA precursor peptides by these key existent biosynthetic enzymes.
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