Journal
ORGANIC LETTERS
Volume 21, Issue 20, Pages 8454-8458Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03218
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Funding
- National Natural Science Foundation of China [21562052, 21462055]
- National First-Rate Construction Discipline of Guizhou Province (Pharmacy) [YLXKJS-YX-04]
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A first example of radical hydroboration and hydrosilylation of gem-difluoroalkenes using ABIN as the radical initiator is described. This protocol features good functional group tolerance, operational simplicity, high atom economy, and easy scale-up, enabling efficient assembly of a wide range of alpha-difluorinated alkylborons and alkylsilanes in moderate to excellent yields. The synthetic utility of these products is demonstrated by further transformation of the C-B bond and C-Si bond into valuable CF2-containing molecules.
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