Journal
ORGANIC LETTERS
Volume 21, Issue 21, Pages 8641-8645Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03251
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21372259, 21472240]
- Fourth Military Medical University [2018XA009]
Ask authors/readers for more resources
Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands were described. The iridium complexes of these chiral diphosphines displayed excellent enantioselectivity and good reactivity in the asymmetric hydrogenation of challenging 1-aryl-substituted dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as an additive dramatically improved the asymmetric induction of these catalysts. This transformation provided a highly efficient and enantioselective access to chiral 1-aryl-substituted tetrahydroisoquinolines, which were of great importance and common in natural products and biologically active molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available