A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

Automated summary

Systemic sclerosis (SSc) involves various ocular manifestations, including eyelid skin alterations, glaucoma, cataracts, and iris abnormalities. The most common ocular involvements in SSc patients are eyelid skin abnormalities, dry eye disease (DED), and retinal abnormalities. Significant positive correlations were found between NFC data and tear breakup time and Ocular Surface Disease Index test values.