Journal
NORDIC JOURNAL OF PSYCHIATRY
Volume 74, Issue 3, Pages 187-193Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08039488.2019.1688389
Keywords
Schizophrenia; cognition; inflammation; IL-6
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Aims: Recent findings suggest that cognitive impairment can be associated with inflammation and immune changes in schizophrenia. We aimed to study possible associations between cytokine levels and cognitive performance in a sample of patients with schizophrenia. Methods: Cognition was assessed with the brief assessment of cognition in schizophrenia in 63 clinically stable outpatients with schizophrenia. Blood was collected and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-alpha, IFN-gamma) were measured by cytometric bead array method. Psychopathological scales were also applied. Results: IL-6 correlated negatively with general cognitive performance (rho = -0.395, p = .017) and positively with antipsychotic dose (rho = 0.412, p = .004). Multiple regression analysis showed that cognitive performance is associated with age and antipsychotic dose (p = .000 and p = .033). Conclusion: The association between IL-6 levels and cognitive performance is dependent on age and antipsychotic dose.
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