Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 129, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2019.104469
Keywords
Mitophagy; Autophagy; Microglia; Ageing; NAD(+); Inflammation
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Funding
- HELSE SoR-OST [2017056]
- Research Council of Norway [262175, 277813]
- Akershus University Hospital Strategic grant [269901]
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In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.
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