Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 129, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2019.104464
Keywords
Basal ganglia; Cortex; Goal-directed behavior; Habits; Obsessive-compulsive disorder; Sapap3
Categories
Funding
- KANAE foundation for the promotion of medical science
- HOKUTO foundation for the promotion of biological science
- Uehara Memorial Life Science Foundation
- Society for Research on Umami Taste
- Salt Science Research Foundation
- JSPS KAKENHI [19H01769, 19H05005]
- Swiss National Science Foundation [PZ00P3_174178]
- Swiss National Science Foundation (SNF) [PZ00P3_174178] Funding Source: Swiss National Science Foundation (SNF)
- Grants-in-Aid for Scientific Research [19H05005, 19H01769] Funding Source: KAKEN
Ask authors/readers for more resources
Goal-directed and habitual actions are essential for normal functioning in everyday life. Goal-directed behaviors are actions that are executed to achieve specific goals. With repetition, such as a daily routine, these goal directed actions become automatized and habitual. However, these useful behaviors can become aberrant, manifesting as key symptoms in several psychiatric disorders, including obsessive-compulsive disorder (OCD). A comprehensive understanding of the neural circuits underlying both aberrant and non-pathological goal-directed and habitual behaviors can lead to improved treatments for OCD. Here we review the preclinical research that has advanced our understanding of the brain structures that control goal-directed and habitual behavior and discuss their relationships to the pathophysiology of OCD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available