Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 39, Issue 12, Pages 1923-1931Publisher
SPRINGER
DOI: 10.1007/s00449-016-1666-x
Keywords
Benzoin gum; Biosynthesis; Silver nanoparticles; Antibacterial; Anti-biofilm; Cytotoxicity
Funding
- Ministry of Trade, Industry & Energy (MOTIE, Korea) [N0000888]
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This study described a simple and green approach for the synthesis of silver nanoparticles (AgNPs) employing benzoin gum water extract as a reducing and capping agent and their applications. The AgNPs were characterized by ultraviolet-visible spectrophotometer, X-ray diffraction pattern, field emission transmission electron microscopy, dynamic light scattering, zeta potential and fourier transform infrared spectroscopy. The AgNPs showed promising antimicrobial activity against various pathogens (Gram-negative, Gram-positive and fungus) and possessed high free radical scavenging activity (104.5 +/- 7.21 % at 1 mg/ml). In addition, the AgNPs exhibited strong cytotoxicity towards human cervical cancer and human lung cancer cells as compared to the normal mouse macrophage cells. Moreover, the AgNPs possessed anti-biofilm activity against Escherichia coli, and compatibility to human keratinocyte HaCaT cells, which suggests the use of dressing with the AgNPs in chronic wound treatment. Therefore, AgNPs synthesized by benzoin gum extract are comparatively green and may have broad spectrum potential application in biomedicine.
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