Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 39, Issue 4, Pages 651-659Publisher
SPRINGER
DOI: 10.1007/s00449-016-1546-4
Keywords
Alternanthera tenella; Anticancer activity; Cell migration assay; Flavonoids; Human breast adenocarcinoma cells; Silver nanoparticles
Funding
- Universiti Teknologi Malaysia
- Fundamental Research Grant Scheme from Ministry of Education, Malaysia [R.J130000.7809.4F465]
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In this study, phyto-synthesis of silver nanoparticles (AgNPs) was achieved using an aqueous leaf extract of Alternanthera tenella. The phytochemical screening results revealed that flavonoids are responsible for the AgNPs formation. The AgNPs were characterised using UV-visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray, transmission electron microscopy, fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction. The average size of the nanoparticles was found to be a parts per thousand 48 nm. The EDX results show that strong signals were observed for the silver atoms. The strong band appearing at 1601-1595 cm(-1) correspond to C-C stretching vibration from dienes in FT-IR spectrum indicating the formation of AgNPs. Human breast adenocarcinoma (MCF-7) cells treated with various concentrations of AgNPs showed a dose-dependent increase in cell inhibition. The IC50 value of the AgNPs was calculated to be 42.5 mu g mL(-1). The AgNPs showed a significant reduction in the migration of MCF-7 cells.
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