4.4 Review

Amyloid-beta-independent regulators of tau pathology in Alzheimer disease

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

Adeno-associated virus vector as a platform for gene therapy delivery

Dan Wang et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study

Hanna Cho et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

Letter Medicine, General & Internal

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease

David Henley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease

Michael F. Egan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Nicolai Franzmeier et al.

NATURE COMMUNICATIONS (2019)

Article Clinical Neurology

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

Theresa M. Harrison et al.

ANNALS OF NEUROLOGY (2019)

Article Neurosciences

Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo

Marc Aurel Busche et al.

NATURE NEUROSCIENCE (2019)

Review Clinical Neurology

A critical appraisal of amyloid-βtargeting therapies for Alzheimer disease

Francesco Panza et al.

NATURE REVIEWS NEUROLOGY (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity

Sudeepti Southekal et al.

JOURNAL OF NUCLEAR MEDICINE (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18

Michael D. Devous et al.

JOURNAL OF NUCLEAR MEDICINE (2018)

Article Clinical Neurology

Longitudinal tau PET in ageing and Alzheimer's disease

Clifford R. Jack et al.

BRAIN (2018)

Article Biochemistry & Molecular Biology

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid- clearance in human astrocytes

Lauren K. Fong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Clinical Neurology

Tau-targeting therapies for Alzheimer disease

Erin E. Congdon et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Medicine, General & Internal

Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease

Lawrence S. Honig et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

Hari Prasad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

A transcriptomic atlas of aged human microglia

Marta Olah et al.

NATURE COMMUNICATIONS (2018)

Article Clinical Neurology

An exploratory clinical study of p38 kinase inhibition in Alzheimer's disease

Philip Scheltens et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)

Article Clinical Neurology

Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?

Corey T. McMillan et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)

Article Clinical Neurology

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

Andrew J. Aschenbrenner et al.

NEUROLOGY (2018)

Article Multidisciplinary Sciences

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Gael Barthet et al.

NATURE COMMUNICATIONS (2018)

Article Neurosciences

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

Alessia Lasorsa et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Medicine, General & Internal

Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders

Rik Ossenkoppele et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Bin1 and CD2AP polarise the endocytic generation of beta-amyloid

Florent Ubelmann et al.

EMBO REPORTS (2017)

Article Biochemistry & Molecular Biology

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

Henne Holstege et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2017)

Article Biochemistry & Molecular Biology

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

Natalia Mast et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Neurosciences

Glial contributions to neurodegeneration in tauopathies

Cheryl E. G. Leyns et al.

MOLECULAR NEURODEGENERATION (2017)

Review Neurosciences

Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

Anastasia G. Efthymiou et al.

MOLECULAR NEURODEGENERATION (2017)

Article Biochemical Research Methods

Generation of pure GABAergic neurons by transcription factor programming

Nan Yang et al.

NATURE METHODS (2017)

Article Clinical Neurology

In vivo staging of regional amyloid deposition

Michel J. Grothe et al.

NEUROLOGY (2017)

Article Multidisciplinary Sciences

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Cheryl E. G. Leyns et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Clinical Neurology

A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease

Susanne Ostrowitzki et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Clinical Neurology

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

Julie M. Zissimopoulos et al.

JAMA NEUROLOGY (2017)

Article Neurosciences

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Tal Nuriel et al.

FRONTIERS IN NEUROSCIENCE (2017)

Review Biochemistry & Molecular Biology

APP mouse models for Alzheimer's disease preclinical studies

Hiroki Sasaguri et al.

EMBO JOURNAL (2017)

Article Medicine, Research & Experimental

18F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease

Niklas Mattsson et al.

EMBO MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Article Clinical Neurology

Fluorodeoxyglucose Metabolism Associated With Tau-Amyloid Interaction Predicts Memory Decline

Bernard J. Hanseeuw et al.

ANNALS OF NEUROLOGY (2017)

Article Clinical Neurology

Tau Positron Emission Tomographic Imaging in Aging and Early Alzheimer Disease

Keith A. Johnson et al.

ANNALS OF NEUROLOGY (2016)

Review Neurosciences

Tau in physiology and pathology

Yipeng Wang et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Review Biochemistry & Molecular Biology

The Cellular Phase of Alzheimer's Disease

Bart De Strooper et al.

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

Kyle W. Anderson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

The amyloid cascade hypothesis: are we poised for success or failure?

Eric Karran et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Clinical Neurology

Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database

John M. Ringman et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2016)

Article Clinical Neurology

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease

Jeffrey L. Cummings et al.

ALZHEIMERS RESEARCH & THERAPY (2016)

Article Clinical Neurology

PART is part of Alzheimer disease

Charles Duyckaerts et al.

ACTA NEUROPATHOLOGICA (2015)

Review Cell Biology

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

Rik van der Kant et al.

DEVELOPMENTAL CELL (2015)

Article Medicine, General & Internal

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis

Willemijn J. Jansen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Neurosciences

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

Erik S. Musiek et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai et al.

NATURE NEUROSCIENCE (2015)

Article Clinical Neurology

Primary age-related tauopathy (PART): a common pathology associated with human aging

John F. Crary et al.

ACTA NEUROPATHOLOGICA (2014)

Article Biochemistry & Molecular Biology

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Christina R. Muratore et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

Natalia Mast et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Neurosciences

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

Anat Boehm-Cagan et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

A three-dimensional human neural cell culture model of Alzheimer's disease

Se Hoon Choi et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Pharmacological chaperones stabilize retromer to limit APP processing

Vincent J. Mecozzi et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Medicine, General & Internal

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Stephen Salloway et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Editorial Material Cell Biology

The A4 Study: Stopping AD Before Symptoms Begin?

Reisa A. Sperling et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Neurosciences

Exercise, APOE genotype, and the evolution of the human lifespan

David A. Raichlen et al.

TRENDS IN NEUROSCIENCES (2014)

Review Neurosciences

Stuck in traffic: an emerging theme in diseases of the nervous system

Jacques Neefjes et al.

TRENDS IN NEUROSCIENCES (2014)

Article Multidisciplinary Sciences

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

Kunihiko Kanatsu et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

PICALM modulates autophagy activity and tau accumulation

Kevin Moreau et al.

NATURE COMMUNICATIONS (2014)

Editorial Material Biochemistry & Molecular Biology

SnapShot: Genetics of Alzheimer's Disease

Rita Guerreiro et al.

Article Neurosciences

Normal cognition in transgenic BRI2-Aβ mice

Jungsu Kim et al.

MOLECULAR NEURODEGENERATION (2013)

Article Biochemistry & Molecular Biology

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

J. Chapuis et al.

MOLECULAR PSYCHIATRY (2013)

Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Chia-Chan Liu et al.

NATURE REVIEWS NEUROLOGY (2013)

Review Neurosciences

Biomarker Modeling of Alzheimer's Disease

Clifford R. Jack et al.

NEURON (2013)

Editorial Material Multidisciplinary Sciences

Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Ina Tesseur et al.

SCIENCE (2013)

Editorial Material Multidisciplinary Sciences

Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Karthikeyan Veeraraghavalu et al.

SCIENCE (2013)

Editorial Material Multidisciplinary Sciences

Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Ashleigh R. Price et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

Robin B. Chan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

Mason A. Israel et al.

NATURE (2012)

Article Multidisciplinary Sciences

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

Paul J. Barrett et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Paige E. Cramer et al.

SCIENCE (2012)

Review Clinical Neurology

Cholesterol Level and Statin Use in Alzheimer Disease II. Review of Human Trials and Recommendations

Nina E. Shepardson et al.

ARCHIVES OF NEUROLOGY (2011)

Article Clinical Neurology

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

Heiko Braak et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Review Biotechnology & Applied Microbiology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Eric Karran et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Neurosciences

Linking lipids to Alzheimer's disease: cholesterol and beyond

Gilbert Di Paolo et al.

NATURE REVIEWS NEUROSCIENCE (2011)

Article Clinical Neurology

Plasma apolipoprotein E and Alzheimer disease risk The AIBL study of aging

V. B. Gupta et al.

NEUROLOGY (2011)

Article Multidisciplinary Sciences

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

Ragna Sannerud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Article Neurosciences

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Kiran Bhaskar et al.

NEURON (2010)

Article Biochemistry & Molecular Biology

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

Robert W. Mahley et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Clinical Neurology

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

Moran Boimel et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

Article Geriatrics & Gerontology

APOE genotype-specific differences in the innate immune response

Michael P. Vitek et al.

NEUROBIOLOGY OF AGING (2009)

Article Clinical Neurology

ACAT as a drug target for Alzheimer's disease

Henri J. Huttunen et al.

NEURODEGENERATIVE DISEASES (2008)

Article Multidisciplinary Sciences

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Aβ accumulation

Alim Muhammad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: Effects of gender, CYP46, and ApoE polymorphisms

Gloria Lena Vega et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Reduction of soluble Aβ and Tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

Salvatore Oddo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Clinical Neurology

Aβ species removal after Aβ42 immunization

James A. R. Nicoll et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)

Article Multidisciplinary Sciences

Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells:: ApoE structure as a potential therapeutic target

SM Ye et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Clinical Neurology

Model-guided microarray implicates the retromer complex in Alzheimer's disease

SA Small et al.

ANNALS OF NEUROLOGY (2005)

Article Multidisciplinary Sciences

Tau suppression in a neurodegenerative mouse model improves memory function

K SantaCruz et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

CNS synaptogenesis promoted by glia-derived cholesterol

DH Mauch et al.

SCIENCE (2001)