Journal
NATURE NEUROSCIENCE
Volume 22, Issue 12, Pages 2111-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-019-0525-x
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Funding
- European Union [ERC-834682 CELLPHASE_AD]
- Fonds voor Wetenschappelijk Onderzoek
- Flanders Institute for Biotechnology
- UK Dementia Research Institute (Medical Research Council)
- UK Dementia Research Institute (Alzheimer's Research UK)
- UK Dementia Research Institute (Alzheimer's Society)
- KU Leuven
- Flemish Government
- Vlaams Initiatief voor Netwerken voor Dementie Onderzoek [135043]
- Geneeskundige Stichting Koningin Elisabeth
- Opening the Future campaign of the Leuven Universitair Fonds
- Belgian Alzheimer Research Foundation
- Alzheimer's Association USA
- Medical Research Council
- Alzheimer's Society
- Alzheimer's Research UK via the Dementia Research Institute
- Fonds voor Wetenschappelijk Onderzoek [G0C9219N]
- BBSRC [BBS/E/B/000C0428, BBS/E/B/000C0427] Funding Source: UKRI
- MRC [UKDRI-1004, UKDRI-1013] Funding Source: UKRI
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Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-beta induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.
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