Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 39, Issue 11, Pages 1711-1716Publisher
SPRINGER
DOI: 10.1007/s00449-016-1646-1
Keywords
Metabolome analysis; Saccharomyces cerevisiae; Proline; Acid stress; Lactic acid
Funding
- JSPS KAKENHI [24246134]
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In Saccharomyces cerevisiae, proline is a stress protectant interacting with other substrate uptake systems against oxidative stress under low pH conditions. In this study, we performed metabolomics analysis to investigate the response associated with an increase in cell growth rates and maximum densities when cells were treated with proline under normal and acid stress conditions. Metabolome data show that concentrations of components of central metabolism are increased in proline-treated S. cerevisiae. No consumption of proline was observed, suggesting that proline does not act as a nutrient but regulates metabolic state and growth of cells. Treatment of lactic acid-producing yeast with proline during lactic acid bio-production improved growth rate and increased the final concentration of lactic acid.
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