Journal
NATURE IMMUNOLOGY
Volume 20, Issue 12, Pages 1584-1593Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0479-x
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Funding
- European Research Council, under the European Union's Horizon 2020 research and innovation programme [ERC CoG648455]
- Fundacao para a Ciencia e a Tecnologia, Portugal [FAPESP/20015/2014, PTDC/MEC-HEM/31588/2017]
- US National Cancer Institute, National Institutes of Health
- Children's Cancer Foundation
- MRC (United Kingdom) [U117573801, MR/P011225/1]
- MRC [MR/P011225/1] Funding Source: UKRI
- Fundação para a Ciência e a Tecnologia [FAPESP/20015/2014, PTDC/MEC-HEM/31588/2017] Funding Source: FCT
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The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive Tcells, and generation and maintenance of memory Tcells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their 'dark side' as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7-IL-7R signaling axis.
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