Journal
NATURE IMMUNOLOGY
Volume 20, Issue 11, Pages 1542-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-019-0495-x
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Funding
- Wellcome Trust [205023/Z/16/Z, 202950/Z/16/Z, 105024/Z/14/Z]
- Wellcome Trust [202950/Z/16/Z] Funding Source: Wellcome Trust
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Quantitative mass spectrometry reveals how CD4(+) and CD8(+) T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machinery and environmental sensors that shape T cell fate. We reveal that lymphocyte environment sensing is controlled by immune activation, and that CD4(+) and CD8(+) T cells differ in their intrinsic nutrient transport and biosynthetic capacity. Our data also reveal shared and divergent outcomes of mTORC1 inhibition in naive versus effector T cells: mTORC1 inhibition impaired cell cycle progression in activated naive cells, but not effector cells, whereas metabolism was consistently impacted in both populations. This study provides a comprehensive map of naive and effector T cell proteomes, and a resource for exploring and understanding T cell phenotypes and cell context effects of mTORC1.
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