Journal
NATURE CELL BIOLOGY
Volume 21, Issue 11, Pages 1334-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-019-0410-6
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Funding
- CNRS, UPMC
- Fondation Les Treilles
- EMBO short-term fellowship
- MERI
- FRM [DEQ20100318258]
- ANR/CIRM joint grant [ANR/CIRM 0001-02]
- BBSRC
- Wellcome Trust
- European Research Council grant (ERC) [220-H75001EU/HSCOrigin-309361]
- NWO/ZonMw [912.15.017]
- BBSRC [BBS/E/D/10002071] Funding Source: UKRI
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It is well established that haematopoietic stem and progenitor cells (HSPCs) are generated from a transient subset of specialized endothelial cells termed haemogenic, present in the yolk sac, placenta and aorta, through an endothelial-to-haematopoietic transition (EHT). HSPC generation via EHT is thought to be restricted to the early stages of development. By using experimental embryology and genetic approaches in birds and mice, respectively, we document here the discovery of a bone marrow haemogenic endothelium in the late fetus/young adult. These cells are capable of de novo producing a cohort of HSPCs in situ that harbour a very specific molecular signature close to that of aortic endothelial cells undergoing EHT or their immediate progenies, i.e., recently emerged HSPCs. Taken together, our results reveal that HSPCs can be generated de novo past embryonic stages. Understanding the molecular events controlling this production will be critical for devising innovative therapies.
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