Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 18, Pages 3018-3025Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1684284
Keywords
Dioscorea oppositifolia L; Dioscoreaceae; norsesquiterpenoids; estrogenic activity
Categories
Funding
- Central Government Guide Local Science and Technology Development Funds [[2016]149, 171100310500]
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Two new norsesquiterpenoids were isolated from the stems and leaves of Dioscorea oppositifolia L., along with 21 known compounds. The structures were elucidated and their estrogenic activities were evaluated, with several compounds showing proliferation activity.
Two new norsesquiterpenoids, dioscopposin A (1) and dioscopposin B (2), as well as 21 known compounds (3-23) were isolated from the stems and leaves of Dioscorea oppositifolia L. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The absolute configurations were deduced by the comparison of experimental and calculated electronic circular dichroism spectra. Estrogenic activity of all the isolated compounds were evaluated using MCF-7 cells proliferation assay and compounds 2, 3, 7, 13, 15, 16, 18 and 21 exhibited proliferation activity.
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