Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 17, Pages 2840-2848Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1675060
Keywords
Ageratina adenophora; endophytic fungus; Phomoxanthone A; Penialidin A; antioxidative activity; cytotoxicity
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Funding
- Science and Technology Support Program of Sichuan Province [2015SZ0201]
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The study isolated two new compounds, Phomoxanthone A and Penialidin A, with significant antioxidative activity and cytotoxicity from the endophytic fungus Ageratina adenophora. This provides a theoretical foundation for the development and utilization of endophytic fungi in Ageratina adenophora as a medicinal substance.
Ageratina adenophora is an invasive plant of global importance and has a broad distribution in the Western Himalayas. Endophtytic fungus Coniochaeta sp.F-8 was found in Ageratina adenophora. In this paper, we aim to investigate the antioxidative activity and cytotoxicity of the metabolites from Coniochaeta sp.F-8. Consequently, two compounds Phomoxanthone A and Penialidin A were isolated from the endophytic fungus of Ageratina adenophora for the first time. The structures of compounds were identified by IR, NMR and ESI-MS methods. Moreover, both of those compounds showed considerable antioxidative activity in vitro and resulted cytotoxicity in mouse embryo fibroblasts cell line Balb/c3T3. The present study provides a theoretical foundation for the development and utilization of endophytic fungi in Ageratina adenophora as a medicinal substance.
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