Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 18, Pages 3049-3055Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1689497
Keywords
Nauclea officinalis; alkaloids; HUVEC proliferation activity; VEGF
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Funding
- Natural & Science Foundation of Hainan Province [20168270]
- Hainan Province Graduate Innovative Research Project [Hys2017-182]
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A new indole alkaloid, naucleofficine H, was isolated from Nauclea officinalis, along with four known alkaloids. These compounds were found to promote HUVEC cell proliferation, with compounds 3 and 5 up-regulating the expression of VEGF and p-ERK in HUVEC cells.
A new indole alkaloid, namely naucleofficine H (1), was obtained from the aqueous extract of Nauclea officinalis, together with four known alkaloids, vincosamide (2), strictosamide (3), angustoline (4) and pumiloside (5). Their structures were characterized by analyzing their physicochemical data including NMR, and HRMS. In addition, five compounds were tested for their proliferation activities. The expression of vascular endothelial growth factor (VEGF), extra-cellular signal-regulated protein kinase 1 and 2 (ERK) and phosphorylation of ERK 1/2 (p-ERK) were also detected in HUVEC treated withbioactive compounds using western blotting. The result showed that these compounds could promote HUVEC cell proliferation. Compounds 3 and 5 could up-regulate VEGF and p-ERK in HUVEC.
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