Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 18, Pages 3126-3130Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1686372
Keywords
Vitexin; 3'-O-acteylvitexin; miR-20a; MICA; breast cancer; MICB
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The natural compound 3'-O-acetylvitexin has shown promising therapeutic effects on TNBC cells by repressing miR-20a and increasing MICA/B expression, indicating its potential as a therapeutic agent for TNBC patients.
The activating immune ligands, MICA/B, act as a kill me signal through the NKG2D receptor expressed on natural killer (NK) cells. Recently, the oncogenic miR-20a was found to mediate immune escape through repressing MICA/B levels in breast cancer (BC) cells. However, targeting miR-20a-MICA/B using natural compounds has rarely been investigated. Our group has successfully isolated 3'-O-acetylvitexin that showed cytotoxic effects against colon cancer cells but has never been evaluated in BC. Our aim is to investigate the effects of 3'-O-acetylvitexin on BC cell lines and to further elucidate its molecular mechanism of action.The results showed that 3'-O-acetylvitex depicted a more pronounced dose-dependent repression of TNBC cellular viability, colonogenicity and migration capacity than Vitexin. 3'-O-acetylvitexin treatment resulted in a marked dose-dependent repression of miR-20a with a concomitant dose-dependent increase in MICA/B expression. In conclusion, 3'-O-acetylvitexin might act as a promising therapeutic agent for TNBC patients.
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