Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 15, Pages 2520-2525Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1684282
Keywords
Ginkgo biloba; cardioprotective activity; acylated flavonol glycoside
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Funding
- National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' [2013ZX09402203]
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Four new flavonol glycosides were isolated from Ginkgo biloba leaves, along with nine known flavonoids and two known lignans. Their structures were determined by spectroscopic analyses, and they showed stronger cardioprotective effects compared to acylated flavonol glycosides.
Four new flavonol glycosides, 5, 7, 5 '-trihydroxy-3 ', 4 '-dimethoxyflavonol-3-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (1), quercetin 3-O-(6-trans-feruloyl)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside (2), kaempferol 3-O-(6-trans-caffeoyl)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside (3), myricetin 3-O-(6-trans-p-coumaroyl)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside (4), together with nine known flavonoids and two known lignans, were isolated from the leaves of Ginkgo biloba. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated. The flavonol glycosides had stronger activity than the acylated flavonol glycosides at the concentration of 50 mu M.
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