Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 14, Pages 2324-2328Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1672685
Keywords
Antimicrobial; Artocarpus; Diaporthe; cytotoxicity; secondary metabolites
Categories
Funding
- Ministry of Research, Technology and Higher Education of Indonesia [859/D3/PG/2018]
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Fractionation and purification of the ethyl acetate extract of Diaporthe lithocarpus from Artocarpus heterophyllus leaves led to the discovery of a new compound, diaporthindoic acid, and several known compounds. Diaporthindoic acid exhibited strong cytotoxicity against murine leukemia P-388 cells. This study represents the first chemical evaluation of fungal Diaporthe derived from Artocarpus.
Fractionation and purification of the ethyl acetate extract of Diaporthe lithocarpus, an endophytic fungus from the leaves of Artocarpus heterophyllus, yielded one new compound, diaporthindoic acid (1), along with seven known compounds (2?8). The new compound was characterized and established by the basis of extensive spectroscopic methods including NMR (1D and 2D) and HRMS. Compound 6 showed the best citotoxicity against murine leukemia P-388 cells with an IC50 value of 0.41??g/mL. All compounds (1?8) were also tested for their antimicrobial activities. To the best of our knowledge, this is the first chemical evaluation of fungal Diaporthe derived from Artocarpus.
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