Journal
NANOSCALE RESEARCH LETTERS
Volume 14, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-019-3152-2
Keywords
Radiosensitizing effect; Gadolinium oxide nanocrystals; DNA damage; Apoptosis; Cytotoxic autophagy; Carbon ion radiotherapy
Funding
- National Key Research and Development Program [2017YFC0108500]
- National Key Technology Support Program of the Ministry of Science and Technology of China [2015BAI01B11]
- National Natural Science Foundation of China [11805247]
Ask authors/readers for more resources
Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and biological advantages. However, only a few metallic nanoparticles have been used to improve carbon ion irradiation. In this study, gadolinium oxide nanocrystals (GONs) were synthesized using a polyol method to decipher the radiosensitizing mechanisms in non-small cell lung cancer (NSCLC) cell lines irradiated by carbon ions. The sensitizer enhancement ratio at the 10% survival level was correlated with the concentration of Gd in NSCLC cells. GONs elicited an increase in hydroxyl radical production in a concentration-dependent manner, and the yield of reactive oxygen species increased obviously in irradiated cells, which led to DNA damage and cell cycle arrest. Apoptosis and cytostatic autophagy were also significantly induced by GONs under carbon ion irradiation. The GONs may serve as an effective theranostic material in carbon ion radiotherapy for NSCLC.Graphical
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available