Journal
NANOMEDICINE
Volume 15, Issue 3, Pages 289-302Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0220
Keywords
gene expression; gold nanoparticles; histopathology; PEG-coating; proinflammatory cytokines
Funding
- Deanship of Scientific Research at King Saud University [RGP-009]
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Aim: To compare the effects of 5- and 50-nm naked and PEG-coated gold nanoparticles (AuNP) on proinflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) expression and histopathological changes in liver and kidneys of rats. Materials & methods: Rats were injected with different nanoparticles and sacrificed after 24 h. Results: Both 5- and 50-nm AuNPs, and 50-nm PEG-AuNPs caused granular clumping of cytoplasm, edema and hydropic dystrophy in hepatic cells. Naked AuNPs of both sizes caused mild shrinkage, whereas 50-nm PEG-AuNPs enlarged the Bowman's space and capsule. Larger nanoparticles produced more profound mRNA expression of cytokines in both the organs. Conclusion: These findings suggest the roles of particle size and coating on immunological response and histopathological changes.
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