4.8 Article

All-in-one theranostic nanoplatform with controlled drug release and activated MRI tracking functions for synergistic NIR-II hyperthermia-chemotherapy of tumors

Journal

NANO RESEARCH
Volume 12, Issue 12, Pages 2971-2981

Publisher

TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-019-2540-3

Keywords

hyperthermia; magnetic resonance; NIR-II window; drug delivery; chemotherapy

Funding

  1. National Natural Science Foundation of China [21473243]
  2. Six Talent Peaks Project in Jiangsu Province [SWYY-243]

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Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalize medical treatment. However, the development of a non-invasive drug reporting platform still remains challenging. Herein the design of a novel synthetic magnetic resonance imaging (MRI) agent for drug release tracking (SMART) is reported, which integrates photothermal core and paramagnetic ion/drug loading shell with a thermal valve in a hybrid structure. Through near-infrared (NIR)-II photothermal effect originating from inner Au-Cu9S5 nanohybrid core, burst release of drugs loaded in the mesoporous silica shell is achieved. The concomitant use of a phase change material not only prevents premature drug release, but also regulates heating effect, keeping local temperature below 45 degrees C, enabling synergistic chemotherapy and mild hyperthermia in vitro and in vivo. Furthermore, the drug release from SMART facilitates proton accessibility to the paramagnetic ions anchored inside mesopores channels, enhancing longitudinal T-1 relaxation rate and displaying positive signal correlation to the amount of released drug, thus allowing non-invasive real-time monitoring of drug release event. The current study highlights the potential of designed MRI nanophores such as SMART for real-time and in-situ monitoring of drug delivery for precision theranostic applications.

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