Journal
NANO LETTERS
Volume 19, Issue 12, Pages 8749-8757Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b03456
Keywords
Molecular bottlebrush; nanomotor; particle motion; unimolecular nanoparticles
Categories
Funding
- National Natural Science Foundation of China [51533009, 21805318]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
- Guangdong Province Young Scholar [2018B030306007]
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Inspired by the natural motors capable of performing multiple tasks in complex living environments, synthetic nanomotors emerge as a potential vehicle for revolutionizing biomedical processes. Yet current motors suffer from decreased and even completely hindered motion in a complex physiological environment, shadowing the future of this booming field. To address this problem, a unimolecular nanomotor based on molecular bottlebrush (MBB) of sub-100 nm size is reported. This motor is constructed precisely via controlled radical polymerization and click chemistry and propelled with biocompatible catalase. Such a molecular nanomotor possesses tadpole-like asymmetry and is able to overcome Brownian motion, and demonstrates strong directional propulsion (linear and coiled cyclic trajectories) in a viscous tumor microenvironment gel model at an ultralow hydrogen peroxide level of 2 mM (0.006%). In addition, the molecular nanomotor exhibits superior stability in serum containing cell medium and good biocompatibility in blood. Such molecular bottlebrush based nanomotors may represent a unique platform for overcoming the tissue penetration barrier.
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