Journal
NANO LETTERS
Volume 19, Issue 11, Pages 7935-7940Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b03048
Keywords
Magnetic resonance force microscopy; nanoscale magnetic resonance imaging; scanning probe microscopy; nuclear magnetic resonance
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Funding
- Swiss National Science Foundation (SNFS) through the National Center of Competence in Research in Quantum Science and Technology (NCCR QSIT)
- Swiss National Science Foundation (SNFS) through Sinergia Grant [CRSII5_177198/1]
- European Research Council through the ERC Starting Grant NANOMRI [309301]
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Magnetic resonance force microscopy (MRFM) is a scanning probe technique capable of detecting MRI signals from nanoscale sample volumes, providing a paradigm-changing potential for structural biology and medical research. Thus far, however, experiments have not reached sufficient spatial resolution for retrieving meaningful structural information from samples. In this work, we report MRFM imaging scans demonstrating a resolution of 0.9 nm and a localization precision of 0.6 nm in one dimension. Our progress is enabled by an improved spin excitation protocol furnishing us with sharp spatial control on the MRFM imaging slice, combined with overall advances in instrument stability. From a modeling of the slice function, we expect that our arrangement supports spatial resolutions down to 0.3 nm given sufficient signal-to-noise ratio. Our experiment demonstrates the feasibility of subnanometer MRI and realizes an important milestone toward the three-dimensional imaging of macromolecular structures.
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