Journal
MOLECULES
Volume 24, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/molecules24224093
Keywords
citrus flavonoids; neohesperidin; anti-aging activity; chronological lifespan; synergistic effect
Funding
- National Natural Science Foundation [31772260]
- Chongqing Graduate Student Innovation Project [CYS16081]
- Program for Chongqing Municipal Education Commission [KJQN201901227]
- Foundation of Engineering Technology Research Center of Characteristic Biological Resources in Northeast of Chongqing
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The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have been explored in the current literature. However, the studies on the synergistic effects between the different flavonoid compounds were quite limited in previous reports. In this study, by using a high throughput assay, we tested the synergistic effects between different citrus flavonoids throughout the yeast's chronological lifespan (CLS). We studied the effect of four flavonoid compounds including naringin, hesperedin, hesperitin, neohesperidin, as well as their different combinations on the CLS of the yeast strain BY4742. Their ROS scavenging ability, in vitro antioxidant activity and the influence on the extracellular pH were also tested. The results showed that neohesperidin extended the yeast's CLS in a concentration-dependent manner. Especially, we found that neohesperidin showed great potential in extending CLS of budding yeast individually or synergistically with hesperetin. The neohesperidin exhibited the strongest function in decreasing the reactive oxygen species (ROS) accumulation in yeast. These findings clearly indicated that neohesperidin is potentially an anti-aging citrus flavonoid, and its synergistic effect with other flavonoids on yeast's CLS will be an interesting subject for future research of the anti-aging function of citrus fruits.
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