Journal
MOLECULES
Volume 24, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/molecules24224033
Keywords
Isatis tinctoria roots; alkaloids; structure identification; anti-inflammatory activity
Funding
- National Natural Science Foundation of China [81573571, 81673570]
- Excellent Academic Leaders Program of Shanghai [16XD1403500]
- programs of the High Level University Innovation Team
- Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine
- Shanghai Scientific and Technological Innovation Program [18401931100]
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As our ongoing research project on Ban Lan Gen (Isatis tinctoria roots), a total of 23 alkaloids were obtained. Compounds 1 and 2 contain an unusual C-C bond between the 2(1H)-quinolinone moiety and the phenol moiety and between the 2(1H)-quinolinone moiety and the 1H-indole moiety, respectively. Compound 3 possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound 23 was deduced as a new indole alkaloid glycoside. Compounds 4-7 were identified as four new natural products by extensive spectroscopic experiments. Additionally, the anti-inflammatory activity was assessed based on nitric oxide (NO) production using Lipopolysaccharide-stimulated RAW264.7 macrophages. Compounds 9, 15, and 17 showed inhibitory effects with IC50 values of 1.2, 5.0, and 74.4 mu M.
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