Journal
MOLECULES
Volume 24, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/molecules24213886
Keywords
protozoan diseases; parasitic; giardiasis; leishmaniasis; malaria; trichomoniasis; trypanosomiasis
Funding
- Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1D1A1A01056620, NRF-2014M3C1A3054139, NRF-2018M3A9C8024360]
- National Research Foundation of Korea [2014M3C1A3054139, 2018M3A9C8024360] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012-2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.
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