Journal
BIOPHYSICAL JOURNAL
Volume 111, Issue 3, Pages 577-588Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2016.06.024
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Funding
- US Army High Performance Computation Research Center
- American Recovery and Reinvestment Act
- US Army Medical Research and Materiel Command, Fort Detrick, MD under the US Institute for Surgical Research, Fort Sam Houston, San Antonio, TX [B_040_2011_USAISR]
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The volume fraction of red blood cells (RBCs) in a capillary affects the degree to which platelets are promoted to marginate to near a vessel wall and form blood clots. In this work we investigate the relationship between RBC hematocrit and platelet adhesion activity. We perform experiments flowing blood samples through a microfluidic channel coated with type 1 collagen and observe the rate at which platelets adhere to the wall. We compare these results with three-dimensional boundary integral simulations of a suspension of RBCs and platelets in a periodic channel where platelets can adhere to the wall. In both cases, we find that the rate of platelet adhesion varies greatly with the RBC hematocrit. We observe that the relative decrease in platelet activity as hematocrit falls shows a similar profile for simulation and experiment.
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