Journal
MOLECULAR PSYCHIATRY
Volume 25, Issue 2, Pages 243-253Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41380-019-0555-5
Keywords
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Funding
- European Union [LSHM-CT- 2007-037286]
- Horizon 2020 [695313]
- ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) [PR-ST-0416-10004]
- BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) [MR/N027558/1]
- Human Brain Project (HBP SGA 2) [785907]
- FP7 project MATRICS [603016]
- Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) [MR/N000390/1]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Bundesministeriumfur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, Forschungsnetz AERIAL 01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940/2]
- Medical Research Foundation
- National Institute for Health (NIH) [5U54EB020403-05, 1R56AG058854-01]
- ANR [AF12-NEUR0008-01-WM2NA, ANR-12-SAMA-0004]
- Eranet Neuron [ANR-18-NEUR00002-01]
- Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- Assistance-Publique-Hopitaux-de-Paris
- INSERM (interface grant), Paris Sud University IDEX 2012
- Fondation de l'Avenir [AP-RM-17-013]
- National Institutes of Health
- Science Foundation Ireland [16/ERCD/3797]
- U.S.A. (Axon, Testosterone and Mental Health during Adolescence) [RO1 MH085772-01A1]
- NIH Consortium grant [U54 EB020403]
- cross-NIH alliance
- Fondation de France [00081242]
- Fondation pour la Recherche Medicale [DPA20140629802]
- Medical Research Council [MR/R00465X/1, MR/S020306/1]
- MRC [MR/R00465X/1, MR/S020306/1, MR/N000390/1, MC_PC_19009] Funding Source: UKRI
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Mental disorders represent an increasing personal and financial burden and yet treatment development has stagnated in recent decades. Current disease classifications do not reflect psychobiological mechanisms of psychopathology, nor the complex interplay of genetic and environmental factors, likely contributing to this stagnation. Ten years ago, the longitudinal IMAGEN study was designed to comprehensively incorporate neuroimaging, genetics, and environmental factors to investigate the neural basis of reinforcement-related behavior in normal adolescent development and psychopathology. In this article, we describe how insights into the psychobiological mechanisms of clinically relevant symptoms obtained by innovative integrative methodologies applied in IMAGEN have informed our current and future research aims. These aims include the identification of symptom groups that are based on shared psychobiological mechanisms and the development of markers that predict disease course and treatment response in clinical groups. These improvements in precision medicine will be achieved, in part, by employing novel methodological tools that refine the biological systems we target. We will also implement our approach in low- and medium-income countries to understand how distinct environmental, socioeconomic, and cultural conditions influence the development of psychopathology. Together, IMAGEN and related initiatives strive to reduce the burden of mental disorders by developing precision medicine approaches globally.
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