Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 64, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201900532
Keywords
cognition; healthy aging; InCHIANTI; metabolomics; nuts
Categories
Funding
- Italian Ministry of Health [PE-2011-02350413]
- U.S. Intramural Research Program at the National Institute on Aging
- INC International Nut and Dried Fruit Council [FBG307906]
- Generalitat de Catalunya's Agency AGAUR [2017SGR1546]
- Carlos III Institute of Health [CD16/00157, CP15/00100]
- European Social Fund (ESF) [CD16/00157, CP15/00100]
- APIF-INSA of University of Barcelona
- ICREA under the ICREA Academia programme
- NATIONAL INSTITUTE ON AGING [ZIAAG001050] Funding Source: NIH RePORTER
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Scope The association between self-reported dietary intake and urinary metabolomic markers of habitual nut exposure with cognitive decline over a 3-year follow-up in an older Italian population is prospectively evaluated. Methods and results A total of 119 older participants are selected, based on self-referred nut intake: the non-nut consumer (n = 72) and the regular consumer (>= 2.9 g d(-1), n = 47). Nut exposure is measured at baseline either with the use of a validated food frequency questionnaire or with an HPLC-Q-ToF-MS metabolomic approach. Three years after, 28 from the nonconsumers and 10 from the consumers experienced cognitive decline. Dietary nut exposure is characterized by urinary metabolites of polyphenols and fatty acids pathways. Nut consumption estimated either by the dietary marker or by the urinary marker model is in both cases associated with less cognitive decline (OR: 0.78, 95% CI: 0.61,0.99; p = 0.043 and OR: 0.995, 95% CI: 0.991,0.999; p = 0.016, respectively) with AUCs 73.2 (95% CI: 62.9, 83.6) and 73.1 (62.5, 83.7), respectively. Conclusions A high intake of nuts may protect older adults from cognitive decline. Metabolomics provides accurate and complementary information of the nut exposure and reinforces the results obtained using dietary information.
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