Journal
MOLECULAR NEUROBIOLOGY
Volume 57, Issue 3, Pages 1405-1417Publisher
SPRINGER
DOI: 10.1007/s12035-019-01832-1
Keywords
Substantia nigra; Dopamine; Alpha-synuclein; Iron; Manganese; Oxidative stress; Chelating agents
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Research on the etiopathogenesis of Parkinson's disease (PD) has in the very recent years earned many insightful cues about the involvement of xenobiotics and metal pollutants in the onset and exacerbation of this neurodegenerative disorder. Furthermore, particularly for metal pollutants, the hypothesis about the role exerted by impaired mitochondrial function is gaining a leading causative role. In this review, we outline the role of environmental pollution in the pathogenesis of PD, as the prolonged exposure to xenobiotics may account for the majority of PD reported cases, expanding the debate also about some suggested therapeutic approaches.
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