Journal
MOLECULAR MEDICINE REPORTS
Volume 21, Issue 1, Pages 282-290Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2019.10795
Keywords
diabetic peripheral neuropathy; hydrogen-rich saline; mitochondrial ATP-sensitive potassium channels; oxidative stress
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Funding
- National Natural Science Fund of China [81671888]
- Natural Science Foundation of Tianjin [18JCYBJC94400]
- Science & Technology Development Fund of Tianjin Education Commission for Higher Education [2017KJ194]
- Youth Incubating Fund of Tianjin Medical University General Hospital [ZYYFY2016036]
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It has previously been demonstrated that hyperglycemia-induced oxidative stress and inflammation are closely associated with the development of diabetic complications, including diabetic neuropathy. Additionally, mitochondrial ATP-sensitive potassium (Mito-K-ATP) channels play a homeostatic role on blood glucose regulation in organisms. Molecular hydrogen (H-2) exhibits anti-inflammatory, anti-antioxidative and anti-apoptotic properties and can be used to treat more than 71 diseases safely. In addition, the diabetes animal models which are set up using streptozotocin (STZ) injection, is a type of high long-term stability, low animal mortality rate and security method. The aim of the current study was to assess the value of hydrogen-rich saline (HS) in diabetic peripheral neuropathy (DPN) treatment and to determine its associated mechanisms in STZ-induced diabetic experimental rats. Additionally, the effects of the Mito-K-ATP channels, oxidative stress, inflammatory cytokines and apoptosis on DPN were also evaluated. From week 5 of STZ injections, HS (2.5, 5 and 10 ml/kg) was injected into the rat abdominal cavity every day for a period of 4 weeks. The results of the current study demonstrated that HS significantly reduced behavioral, biochemical and molecular effects caused by DPN. However, 5-hydroxydecanoate, a selective Mito-K-ATP channels general pathway inhibitor, partially eliminated the therapeutic effect of HS on DPN. These results indicated that the use of HS may be a novel strategy to treat DPN by activating the Mito-K-ATP pathway and reducing oxidative stress, inflammatory cytokines and apoptosis.
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