Journal
BIOPHYSICAL JOURNAL
Volume 111, Issue 12, Pages 2711-2721Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2016.11.001
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Funding
- LabeX LaSIPS [ANR-10-LABX-0040-LaSIPS, ANR-11-IDEX-0003-02]
- endowment in cardiovascular cellular engineering from the AXA Research Fund
- Gaspard Monge doctoral fellowship from Ecole Polytechnique
- Ecole Normale Superieure
- Fondation Lefoulon-Delalande
- AXA Research Fund
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We investigate the mechanical conditions leading to the rupture of the plasma membrane of an endothelial cell subjected to a local, compressive force. Membrane rupture is induced by tilted microindentation, a technique used to perform mechanical measurements on adherent cells. In this technique, the applied force can be deduced from the measured horizontal displacement of a microindenter's tip, as imaged with an inverted microscope and without the need for optical sensors to measure the microindenter's deflection. We show that plasma membrane rupture of endothelial cells occurs at a well-defined value of the applied compressive stress. As a point of reference, we use numerical simulations to estimate the magnitude of the compressive stresses exerted on endothelial cells during the deployment of a stent.
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