Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 71, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mam.2019.10.003
Keywords
Neurodegeneration; Mitochondria; Mitophagy; Calcium; Reactive oxygen species
Funding
- Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) [2017/14713-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- FAPESP, Centro de Pesquisa, Inovacao e Difusao de Processos Redox em Biomedicina [2013/07937-8]
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The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders.
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